My Top 1000 Songs #229: The Big Ship
Brian Eno, of course, is the exception. 1975's Another Green World in particular, one of my favorite albums, includes a number of soul-stirring non-vocal pieces among the vocal tracks. I was going to go with "In Dark Trees," for purely personal reasons; but opted instead for "The Big Ship." This one seems a little more universal, at least judging by the fact that it's been used in a half-dozen or so soundtracks. There's clearly something about it that strikes a chord for a lot of people.
Here's what I said about it in Jittery White Guy Music (the book):